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Ege Üniversitesi Hemşirelik Yüksekokulu, İç Hastalıkları Hemşireliği Recently, biologic agents have been frequently used in various clinical settings, especially oncology units. Nowadays, new biologic agents have been joined to the implementation. There are major responsibilities of nurses within helath care team related to use and patient management of biologic agents. However, in our country, there are limited literature that nurses require about management of patients received biologic therapy. In this review, we focused on responsibilities of nurses in use of biologic agents. Keywords : Antibodies, monoclonal; biological therapy; drug monitoring/ methods/nursing; infusions, intravenous; nurse's role; nursing assessment; oncologic nursing/methods