TURKISH JOURNAL OF ONCOLOGY 2017 , Vol 1 , Num 3
The Prognostic Effects of Temporal Muscle Thickness and Inflammatory-Nutritional Parameters on Survival in Lung Cancer Patients with Brain Metastasis
Havva YEŞİL ÇINKIR1,Hale ÇOLAKOĞLU ER2
1Department of Medical Oncology, Gaziantep University Faculty of Medicine, Gaziantep-Turkey
2Department of Radiology, Gaziantep University Faculty of Medicine, Gaziantep-Turkey
DOI : 10.5505/tjo.2019.2030 OBJECTIVE
Brain metastasis develops in one-third of the patients with adult cancer and it causes significant morbidity and mortality on the patients. In this study, we aimed to show the prognostic effects of temporal muscle thickness and inflammatory (neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic inflammation response index) and prognostic nutritional index on survival in lung cancer patients with brain metastasis.

METHODS
In this study, a total of 94 cancer patients diagnosed with brain metastasis lung cancer were evaluated retrospectively. Routine blood sampling was tested within 10 days of brain MR imaging before the use of steroid therapy.

RESULTS
Temporal muscle thickness was significantly associated with overall survival, according to cut-off 4.32 (95% CI 0.66-0.99; p=0.040). The risk of death increased by 18.8%, with every millimeter reduction in temporal muscle thickness. Neutrophil-lymphocyte ratio, systemic inflammation response index and prognostic nutritional index were associated with overall survival (p=0.002, p=0.008, p=0.001, respectively).

CONCLUSION
The findings showed that the use of temporal muscle thickness and inflammatory-nutritional parameters for the evaluation of sarcopenia were practical and rapid methods. In this group of patients with a short duration of survival, the prognosis of patients can be predicted, and their exposure to toxic treatment may be prevented by the evaluation of sarcopenia. Keywords : Inflammation; lung cancer; sarcopenia; temporal muscle thickness