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¹Temel Onkoloji ABD, Kanser Biyokimyası Bilim Dalı
²Temel Onkoloji ABD
³Prevantif Onkoloji Bilim Dalı
⁴Klinik Onkoloji ABD
⁵Temel Onkoloji ABD, Kanser Biyokimyası Bilim Dalı
⁶Klinik Onkoloji Anabilim Dalı Abnormalities in the control of apoptosis play an important role in tumorigenesis. We investigated the serum levels of an anti-apoptotic protein, survivin, in 44 patients with malignant melanoma using enzyme-linked immunosorbent assay (ELISA). There was no significant difference in the serum survivin level between melanoma patients and controls. In node positive patients the serum levels of survivin were unchanged after Interferon-alpha therapy but serum survivin concentrations were significantly higher in the metastatic patients than the controls. Keywords : Malignant melanoma, survivin, serum