TURKISH JOURNAL OF ONCOLOGY 2017 , Vol 1 , Num 3
Use of miRNA as a Biomarker in Prostate Cancer and New Approaches
Elif Sibel ASLAN1,Sefa ÇETİNKAYA2
1Department of Molecular Biology and Genetics, Biruni University, İstanbul-Turkey
2Department of Molecular Biology and Genetics, Biruni University, İstanbul-Turkey
DOI : 10.5505/tjo.2019.2202

Summary

Prostate cancer has been found to be the most life-threatening disease among men all over the world, given its wide occurrence and partially-successful therapies associated with a high rate of mortality. Thus, meticulous analysis of this cancer and its characteristics, including molecular biology, epigenetic mechanisms and markers during tumor development, may provide the scientists with valuable insights to design the therapeutic protocol with improved efficiency and low rate of failure and limited further side effects, such as infertility. Moreover, the risk associated with the current invasive procedures on prostate cancer patients has prompted researchers to invest effort in the discovery of being less-invasive and more advantageous procedures based on the patient"s own physiological and anatomical characteristics. This paper reviews past and present studies on epigenetics and molecular markers of prostate cancer, as well as the designed therapies. Additionally, we present a future vision and prospect of the current treatments.