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¹Department of Medical Oncology, SBU Bozyaka İzmir Training and Research Hospital, İzmir-Turkey
²Department of Pathology, SBU Bozyaka İzmir Training and Research Hospital, İzmir-Turkey
³Department of Radiology, SBU Bozyaka İzmir Training and Research Hospital, İzmir-Turkey
⁴Department of Medical Education, Ege University Faculty of Medicine, İzmir-Turkey
⁵Department of General Surgery, SBU Bozyaka Training and Research Hospital, İzmir-Turkey DOI : 10.5505/tjo.2018.1771 Undifferentiated pleomorphic sarcoma (UPS) is most frequently observed in the extremities but rarely in the retroperitoneum. The present treatment for patients with metastatic or unresectable UPS in the first-line setting includes doxorubicin administration with or without ifosfamide. We present a case of a 68-year-old woman who presented with a retroperitoneal giant mass. The patient underwent surgery, the mass was removed, and the final diagnosis was UPS. The postoperative stage included soft tissue metastases. After three cycles of gemcitabine chemotherapy, computed tomography findings revealed the absence of soft tissue metastases. The patient has remained on regular follow-up over the past two years since chemotherapy with no symptoms of disease recurrence. The findings of this case demonstrate that patients with retroperitoneal UPS may benefit from single-agent gemcitabine chemotherapy. Keywords : Cardiac failure; complete remission; gemcitabine; undifferentiated pleomorphic sarcoma