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¹Department of Internal Medicine, Abant İzzet Baysal University Training and Research Hospital, Bolu-Turkey
²Department of Medical Oncology, Abant İzzet Baysal University, Training and Research Hospital, Bolu-Turkey
³Department of Pathology, Abant İzzet Baysal University, Training and Research Hospital, Bolu-Turkey DOI : 10.5505/tjo.2019.1821 Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It can be diagnosed at a late stage due to the lack of early symptom onset and its non-pathognomonic symptoms. Metastatic regions often include the lung, lymph nodes, bones, and adrenal glands. Soft tissue and central nervous system (CNS) metastases are extremely rare. The incidence of CNS metastasis ranges from 0.6% to 1.7%. Curative treatment is liver transplantation or resection in early stages. In advanced stages, local therapies include transarterial chemoembolization and radioembolization. Systemic treatments, such as sorafenib, regorafenib, ramucirumab, and nivolumab, are applied in the metastatic stage. We aimed to present with literature the case of HCC that was diagnosed incidentally and had rare metastasis of soft tissue and CNS and long-term overall survival. Keywords : Brain metastasis; hepatocellular carcinoma; incidentally diagnosed