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¹Department of Otolaryngology, İstanbul Florence Nightingale Hospital, Head and Neck Surgery, İstanbul-Turkey
²Department of Radiation Oncology, Gayrettepe Florence Nightingale Hospital, İstanbul-Turkey
³Department of Nuclear Medicine, Koç University Hospital, İstanbul-Turkey
⁴Department of Plastic and Reconstructive Surgery, Liv Hospital, İstanbul-Turkey
⁵Department of Pathology, Gayrettepe Florence Nightingale Hospital, İstanbul-Turkey DOI : 10.5505/tjo.2019.2054 Oropharyngeal squamous cell carcinoma is very uncommon among young children. This is a case report of a 4-year-old boy who was referred from another country with a history of a left-sided neck mass resected 5 months prior to his arrival. Three pathologists gave 3 different pathological diagnoses from the same specimen. A computed tomography scan of the neck indicated a mass located at the base of the tongue. A lesion biopsy confirmed a diagnosis of poorly differentiated carcinoma with p16 positivity and focal human papillomavirus positivity. The decision of the multidisciplinary board was to use radiation treatment as single-modality therapy. The patient completed the treatment and almost 5 years have passed uneventfully. This very rare occurrence of squamous cell carcinoma appears to have been resolved without any major consequences. Keywords : Head and neck; oropharyngeal cancer; pediatric radiotherapy; pediatric tumors; tongue tumor