Dosimetric and clinical comparison of the effects of surgical type on the risk of developing radiationinduced non-rectal bowel toxicity in patients with gynecologic cancer who have received adjuvant radiotherapy.
METHODS
36 patients who meet study criteria were retrospectively evaluated and classified as laparoscopy (group
1) and open surgery (group 2). Intestinal volumes that received a 10% range of total radiotherapy dose
at 10% (V10%) to 100% (V100%) and dosimetric data (V40-45 Gy, Dmax.) were obtained from the dosevolume
histogram. The toxicities were graded acute and late according to Radiation Therapy Oncology
Group (RTOG) scoring.
RESULTS
The median follow-up was 55 months in group 1 and 37 months in group 2. Grade 2 acute bowel toxicity
was observed in seven patients (38.9%) in group 1 and three patients (16.7%) in group 2. One patient in
group 1 was diagnosed with ileus as late toxicity requiring surgery.There was no significant difference
between the groups concerning surgical type and toxicity development.
CONCLUSION
A similar risk of developing radiation-induced non-rectal bowel toxicity in patients who underwent
laparoscopic or open surgery has been demonstrated in this study. However, due to the small number of
patients, prospective studies with large sample sizes are needed for the correct interpretation.