2Deparment of Endocrinology and Metabolism, Muş State Hospital, Muş-Türkiye
3Deparment of Medical Oncology, Gazi University Faculty of Medicine, Ankara-Türkiye
4Deparment of Internal Medicine, Ankara City Hospital, Ankara-Türkiye DOI : 10.5505/tjo.2022.3531 OBJECTIVE
In our study, we aimed to determine the clinicopathological and prognostic factors and their effects on overall survival (OS) and disease-free survival (DFS) in patients who underwent curative resection for gastric cancer and did not have lymph node metastasis.
METHODS
A total of 138 patients followed for lymph node-negative gastric cancer between 2001 and 2016 were
included in the study. The effects of clinicopathological and prognostic factors such as age, sex, tumor localization,
tumor differentiation, tumor TNM stage, type of surgery, lymphovascular invasion, perineural
invasion, presence of Helicobacter pylori, tumor size, histopathologic subtype of the tumor, complete
blood count, tumor markers, and adjuvant treatments on OS and DFS were analyzed.
RESULTS
In the current study, Eastern Cooperative Oncology Group (ECOG) performance score before adjuvant
treatment (hazard ratio [HR]=2.320; p<0.001), largest tumor diameter (HR=1.198; p=0.029), post-operative
carbohydrate antigen 19-9 (CA19-9) level (HR=1.104; p=0.047), and post-operative carcinoembryonic
antigen (CEA) level (HR=1.183; p=0.043) were found to be independent predictors of recurrence
rate. In addition, ECOG score before adjuvant treatment (HR=2.585; p<0.001), post-operative CEA
level (HR=1.128; p=0.005), and post-operative CA 19-9 level (HR=1.080; p=0.006) were independent
predictors of mortality risk in OS analysis.
CONCLUSION
Some clinicopathological and prognostic factors, such as ECOG score, largest tumor diameter, post-operative
CA 19-9 level and post-operative CEA level, could assist us to predict recurrence and mortality
in node-negative gastric cancer patients who underwent curative resection. More comprehensive studies
are required to be carried out in this context.