2Department of Medical Oncology, Gazi University, Ankara-Türkiye
3Department of Pathology, Gazi University, Ankara-Türkiye DOI : 10.5505/tjo.2024.4461 OBJECTIVE
Maspin is a member of the serpin family that targets proteinases and exhibits characteristics of a tumor suppressor protein. The aim of our study is to evaluate the impact of maspin expression on survival rates in patients diagnosed with locally advanced rectal cancer.
METHODS
A retrospective analysis was conducted on a dataset of 60 patients who had received a histopathological
diagnosis of rectal cancer. Maspin expression was assessed using the Ventana Benchmark XT device with
automatic immunohistochemical staining via the streptavidin-biotin immunoperoxidase technique. A
survival analysis was performed by examining maspin in the specimens of these patients.
RESULTS
In terms of maspin staining, 37 patients (61.7%) were negative, while 23 patients (38.3%) were positive
(18 cytoplasmic, 2 nuclear, and 3 both). The 3-year overall survival (OS) was 91.3% in maspin-positive
patients and 73% in maspin-negative patients. Clinical T stage was significantly related to OS (p=0.028).
Multivariate analysis showed nuclear maspin staining was significantly associated with DFS (p=0.004),
and T stage was a significant factor for OS, independent of nuclear maspin expression (p=0.011).
CONCLUSION
Our study underscores the strong link between nuclear maspin staining and disease-free survival in
rectal cancer patients, highlighting its promising potential as a prognostic biomarker for future research.