2Department of Urology, Trakya University Faculty of Medicine, Edirne-Türkiye
3Department of Pathology, Kütahya University of Health Sciences Faculty of Medicine, Kütahya-Türkiye
4Department of Urology, Ekol Hospital, Edirne-Türkiye-Türkiye DOI : 10.5505/tjo.2024.4455 OBJECTIVE
Modern radiotherapy (RT) techniques aim to preserve normal tissues as much as possible, though some normal tissue may inevitably be included in the target volume. The study aimed to evaluate the potential protective role of amifostine and L-carnitine against radiation-induced bladder toxicity and compare their effects.
METHODS
Experiments were conducted on 30 male Wistar Albino rats, divided into four groups: Control, AMI +
RT, LC + RT, and RT alone. All groups received a 20 Gy dose of radiation, and histopathological evaluations
were performed.
RESULTS
Statistically significant differences were found in epithelial desquamation, stromal edema, and vessel
wall thickness in irradiated rats. Amifostine significantly decreased epithelial desquamation and vessel
wall thickness changes but had no effect on stromal edema. L-carnitine had no statistically significant
protective effect on epithelial desquamation, vessel wall thickness, and stromal edema.
CONCLUSION
This study is the first to demonstrate amifostine"s protective effect against radiation-induced bladder
toxicity in a preclinical setting and to compare it with L-carnitine. Findings suggest that amifostine is
more effective than L-carnitine in protecting against radiation-induced bladder damage.