Nowadays, Gustave-Roussy immunoscoring is used to predict treatment sensitivity and survival, especially in the patient group for which immunotherapy is planned for lung cancer. In this study, we aimed to compare the prognostic importance of systemic inflammatory parameters with the immune score in pancreatic cancer (PC), which is a type of cancer with an immunological and poor prognosis.
METHODS
101 patients diagnosed with PC who were diagnosed or treated in our center between 2014 and 2024
were included in the study. The values of prognostic nutritional index (PNI), neutrophil-to-lymphocyte
ratio (NLR), platelet-to-lymphocyte ratio (PLR), Gustave Roussy immune score (GRIm-s), and
eosinophil-to-monocyte ratio (EMR) were calculated according to laboratory parameters at the time of
diagnosis. Survival and regression analyses were performed inter-groups for each variable.
RESULTS
Cut-off values were calculated for GRIm-s, PNI, NLR, PLR, hemoglobin, albumin, lactate dehydrogenase,
and EMR. In terms of survival analyses, GRIm-s, PNI, hemoglobin, NLR, albumin, and PLR were
statistically significant for OS (p=0.00, p=0.03, p=0.032, p=0.00, p=0.00, p=0.029). In the multivariate
Cox regression analysis, GRIm-s was the most powerful variable affecting OS independently (HR: 2.538,
95% CI: 1.558-4.135, p:0.000).
CONCLUSION
GRIm-s is a reliable and prognostic value in terms of survival in PC. Besides, the predictive ability of that
score is much better than other values.