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¹Division of Cancer Genetics, Department of Basic Oncology, İstanbul University, Institute of Oncology, İstanbul-Türkiye
²Division of Cancer Genetics, Department of Basic Oncology, İstanbul University, Institute of Heath Sciences, İstanbul-Türkiye
³Department of Medical Biology and Genetics, İstanbul Health and Technology University Faculty of Medicine, İstanbul-Türkiye DOI : 10.5505/tjo.2025.4550 Exosomes and their contents play a vital role in forming a unique communication system that carries and transmits signal molecules, which alter the physiological state of cells and are linked to the onset and progression of numerous diseases including cancers. Focusing on exosomal cargo, microRNAs (miRNAs), which are small non-coding, single-stranded RNAs that regulate gene expression of target genes, are suggested to be transferred via exosomes in a selective manner that facilitates cancer progression and dissemination. In this context and through ongoing cancer research, researchers have currently been focusing on exosomal microRNA as a specific communication message delivered from cancer cells to the other cells that plays a crucial role in the immune response, tumor migration, tumor cell invasion, and development of metastasis In this review, we aim to evaluate the expected role of exosome-derived microRNAs in the development of cancer metastasis and their possible role of molecular markers in metastasis sites by the current literature on cancer research. Keywords : Cancer; exosomal microRNAs; metastasis