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İstanbul Üniv. Onkoloji Enstitüsü, Pediatrik Onkoloji BD NSE, ferritin and LDH values have been evaluated in 15 fteuroblastoma cases in comparison with 14 healthy children. The mean NSE, ferritin and LDH values were found to be 112±65 ng/ml, 556±71 ng/ml and 980±560 U/L respectively in 15 patients with neuroblastoffla at diagnosis; the mean values of the same markers in the control group were±11ng/ml, 62±62ng/ml and 279±61 U/L respectively. Thus NSE (p<0.001), ferritin (p<0.02) and LDH (p<0.01) values in neuroblastoma patients were significantly higher than those of the controls. The difference in the mean values of NSE, ferritin and LDH obtained from 9 neuroblastoma patients at diagnosis and at the time of partial or complete response were found to be significant (p<0.05). The mean ferritin value obtained at the time of response were higher in these patients in respect to the control group (p<0.05), on the other hand the NSE and LDH values showed no difference in comparison to the control group (p>0.05). NSE, ferritin and LDH values in 55 serum samples obtained serially during the therapy in 6 patients were found to be correlated with disease activity (p<0.05). Keywords :