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Türkiye Kanserle Savaş Vakfı Onkoloji Merkezi Despite various therapeutic efforts, the death rate from carcinoma of the breast has not fallen significantly, randomized trials testing the value of adjuvant systemic therapy in node negative breast cancer reported improved disease free survival, Therefore, whether to give adjuvant treatment to all node negative breast cancer is discussed widely. The argument has been that such treatment is hazardaus, unpleasant and expensive. Therefore, it is now recommended to the patients with node negative breast cancer only in high risk group. In our clinical investigation, it has been observed that adjuvant systemic chemotherapy is effective on this group patients. In 4-years observation, the rate of disease free survival after operation is 96 percent in radiation therapy plus adjuvant chemotherapy group while 69 percent in only radiation therapy group. Keywords : Node negative breast cancer, adjuvant chemotherapy, high risk factors, prognosis