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İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Pediyatrik Hematoloji-Onkoloji BD., İstanbul Although different from ABC-transporter molecules, there are different mechanisms which have been implicated in transmembrane transport of various substrates. Clinical, genetic and molecular studies have shown that one of this mechanism is associated with intranuclear organism called 'vaults'. In addition to a defective cellular accumulation, drug resistance could involve encapsulation of drug in cytoplasmic vesicles resulting in a diminished accessibility of drug to critical nuclear targets. Keywords :