TURKISH JOURNAL OF ONCOLOGY 2006 , Vol 21 , Num 3
Toxic epidermal necrolysis after cranial radiotherapy and anticonvulsant treatment: a case report
Ruşen COŞAR-ALAS,1 Murat ÇALOĞLU,1 Vuslat YÜRÜT-ÇALOĞLU,1 Mert SAYNAK,1 Hakan KARAGÖL,2 Zafer KOÇAK,1 Cem UZAL1
1Trakya Üniversitesi Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı
2Trakya Üniversitesi Tıp Fakültesi Tıbbi Onkoloji Anabilim Dalı Toxic epidermal necrolysis (TEN) is rare, but, it has been known life treating reaction. It's a mucocutaneous reaction resulting from hypersensitivity to a variety of agents including most anticonvulsants. We report a case of TEN whit occured in a patient with metastatic non-small cell lung carcinona before whole-brain radiation therapy (WBRT) and then received phenytoin (300 mg day-1). Keywords : Anticonvulsants/adverse effects; epidermal necrolysis, toxic/classification/etiology