2Erciyes Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, Kayseri
3Erciyes Üniversitesi Tıp Fakültesi, Medikal Onkoloji Bilim Dalı, Kayseri OBJECTIVES
The aim of this study is to determine the prognostic value of transcription factor nucleer factor kappa B ( N F -κB) in resectable gastric cancer patients treated with concurrent chemoradiotherapy.
METHODS
Forty-nine (35 males, 14 females; median age 55; range 2273 years) resectable gastric cancer patients treated with gastrectomy and adjuvant concurrent chemoradiotherapy were enrolled in this study. All patients received weekly 250 mg/ m2 5-FU chemotherapy and radiotherapy concomittantly after gastrectomy. Then patients received 4 cycles i.v bolus FUFA chemotherapy sequentialy as consolidation treatment 2-4 week after chemoradiotherapy. Immunohistochemistry staining was performed on paraffin embedded tissue. NF-κB monoclonal antibodies were used for the staining.
RESULTS
The progression free surv ival and overall surv ival dif er e nce were anal ised between NF-κB pos it ive and neg at ive groups. For NF-kB a specimen was judged posit ive if more than 10% of the total cancer cells in a single field of view showed a response.
CONCLUSION
In patients who NF-κB was stained more than 10%, the overall survival was worse and there was statistically significant difference between groups. But in two groups, no statistically significant difference due to disease free survival.