2Trakya Üniversitesi Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı,
3Trakya Üniversitesi Tıp Fakültesi, Nükleer Tıp Anabilim Dalı,
4Trakya Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı,
5Trakya Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı OBJECTIVES
To investigate the protective effect of amifostine against radiation induced liver and kidney injury of rats, using scintigraphic and histopathologic parameters.
METHODS
Female Wistar Albino rats were randomly allocated to 3 groups: control, radiotherapy alone (RT), and amifostine+RT (n=10). Single-dose of 600 cGy X-ray was performed with a single field compromised liver and right kidney. Amifostine was administered intraperitoneally at a dose of 400 mg/kg, 30 minutes before irradiation. Scintigraphic evaluation was performed before irradiation and the end of the study at 6 nd month. Histopathologic examinations were performed post mortem.
RESULTS
A clear protective effect of amifostine against radiation-induced late damage in liver and kidney was found with scintigraphic evaluation. In addition, amifostine reduced the decrease of histopathologic changes for both of the tissues.
CONCLUSION
The results showed that amifostine significantly reduced radiation-induced liver and kidney toxicity and therefore warrant additional study in a clinically relevant fractionated model.