TURKISH JOURNAL OF ONCOLOGY
2009 , Vol 24 , Num 4
Chronic lymphocytic thyroiditis and tumor-infiltrating lymphocytes combined in thyroid papillary carcinoma
1Zonguldak Karaelmas Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, Zonguldak2Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, İstanbul OBJECTIVES
This study examined the frequency of chronic lymphocytic thyroiditis (CLT) in thyroid papillary carcinomas (TPC) and the relationship between the presence of tumor-infiltrating lymphocytes (TIL) and CLT.
METHODS
The study included 61 TPC cases. In each case, the presence
of the lymphocyte infiltration in the tumor tissue and nonneoplastic
parenchyma was graded semi-quantitatively using a
scale of 0 to 3. The cases were classified in two groups, TPC including
CLT (Group I) and TPC not including CLT (Group II).
RESULTS
CLT was detected in 26.3% (Group I) of the TPCs and TIL
was observed in 77% of the Group I cases; no lymphoid infiltration
compatible with TIL was detected in Group II. A significant
difference was observed in the TIL density between
Groups I and II.
CONCLUSION
CLT is a frequent finding in TPC, and the presence of TIL is
related to CLT.