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¹Departments of Internal Medicine, Ege University Faculty of Medicine, Izmir
²Departments of General Surgery, Ege University Faculty of Medicine, Izmir
³Departments of Medical Oncology, Ege University Faculty of Medicine, Izmir
⁴Departments of Pathology, Ege University Faculty of Medicine, Izmir Clear cell sarcoma (CCS), (malignant melanoma of soft tissues) is an aggressive, rare soft tissue tumour that occurs predominantly in the extremities of young adults. The treatment of CCS includes surgical excision, adjuvant radiotherapy or chemoterapy according to tumor dissemination. Here we present a 31-year-old male with an advanced stage of CCS that was located in the deep of the sole of right foot. Since CCS is extremely rare, there doesn't exist any standart of care for advanced stage disease. For the treatment, a review of the literature was done and subsequently we decided to perform a bioimmunochemotherapy protocol for the patient which has been thought to work better in these tumors compared to conventional chemotherapeutics alone, and he received a combination treatment of cisplatin, dacarbazine, interleukin-2, interferon-α-2b. After three cycles of treatment, he showed partial response. Although the regimen is quite toxic, it seems to be effective for advanced CCS. Keywords : Bioimmunochemotherapy; clear cell sarcoma