2Marmara Üniversitesi Tıp Fakültesi, Tıbbi Onkoloji Bilim Dalı, İstanbul
3Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Genel Cerrahi Kliniği, İstanbul
4Kocaeli Üniversitesi, Tıp Fakültesi, Tıbbi Onkoloji Bilim Dalı, Kocaeli OBJECTIVES
In our study, prognostic factors associated with overall survival (OS) and disease-free survival (DFS) in patients without lymph node metastasis after curative surgery, were investigated.
METHODS
A total of 113 gastric cancer patients with lymph node negative
who had undergone curative gastrectomy, between 2003
and 2010, were retrospectively analyzed.
RESULTS
In the univariate analysis pT stage (p<0.001), clinical stage
(p<0.001), blood vessel invasion (p=0.033) and recurrence
(p<0.001) were found to be an important prognostic factors
for OS, while pT stage (p=0.004), clinical stage (p=0.001),
blood vessel invasion (p=0.016) and lymphatic vessel invasion
(p=0.031) were important prognostic indicators for DFS. Multivariate
analysis indicated that pT stage, clinical stage, histological
grade and recurrence were independent prognostic
factors for OS. Moreover, when multivariate analysis was performed
for DFS, surgery type, tumor size, pT stage and clinical
stage were found to be independent prognostic indicators.
CONCLUSION
Patients with lymph node negative gastric cancer have a high
curability and survival compared with cases with lymph node
metastasis.