2Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul OBJECTIVES
In this study, it was aimed to clarify the features of patients with rare ovarian cancers (ROC) and to determine the prognostic factors associated with survival.
METHODS
A total of 48 patients with ROC, seen between 2003 and 2011,
were analyzed retrospectively.
RESULTS
There were 12 (25%) germ-cell tumors (GCT), 25 (52.1%)
sex cord-stromal tumors (SCT) and 11 (29.1%) “other” ROC
patients. Significant differences were detected with respect
to age, tumor localization, initial symptom(s) at diagnosis,
surgery type, tumor size, and tumor grade. GCTs were commonly
localized in the left and/or bilateral ovaries, while
SCT and the other ROCs were frequently localized in the
right ovary (p=0.02). Staging at primary surgery was high
in the other ROCs compared with GCTs and SCTs (p=0.02).
Patients with GCT were younger in age (p=0.006) and had
larger (p=0.03) and well-differentiated (p=0.01) tumors than
those with SCTs or the other ROCs. Survivals were similar
among groups.
CONCLUSION
ROCs should be evaluated separately from epithelial ovarian
cancers because of their different biological features and different
natural history.