TURKISH JOURNAL OF ONCOLOGY 2006 , Vol 21 , Num 2
Matrix metalloproteinases and lung cancer
Hilal OĞUZ SOYDİNÇ,1 Hakan ÇAMLICA,2 Derya DURANYILDIZ,3 Esra KAYTAN SAĞLAM,4 Faruk TAŞ,5 Vildan YASASEVER,1 Nejat DALAY3
1İstanbul Üniversitesi Onkoloji Enstitüsü Temel Onkoloji Anabilim Dalı, Kanser Biyokimyası Bilim Dalı, İstanbul
2İstanbul Üniversitesi Onkoloji Enstitüsü Temel Onkoloji Anabilim Dalı, Prevantif Onkoloji Anabilim Dalı, İstanbul
3İstanbul Üniversitesi Onkoloji Enstitüsü Temel Onkoloji Anabilim Dalı, İstanbul
4İstanbul Üniversitesi İstanbul Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı, İstanbul
5İstanbul Üniversitesi Onkoloji Enstitüsü Klinik Onkoloji Anabilim Dalı OBJECTIVES
The aim of this study was to determine the pretreatment levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) in lung cancer patients.

METHODS
We investigated the serum MMP-9 and TIMP-1 values in 20 lung cancer patients by ELISA and the results were compared with the controls (n=20).

RESULTS
MMP-9 (p<0.001) and TIMP-1 (p<0.001) values of patients were significantly higher than the controls.

CONCLUSION
Our data indicate that detection of serum levels of MMP-9 and TIMP-1 can be used as diagnostic parameters for lung cancer. Keywords : Gelatinase B; lung cancer; lung/metabolism/radiation e ffects; lung neoplasms/blood/enzymology /radiotherapy; Matrix Metalloproteinases; MMP 9; tissue inhibitor of Metalloproteinase- 1