TURKISH JOURNAL OF ONCOLOGY
2016 , Vol 31 , Num 1
Relationship Between IL-18 and Bone Metastasis in Female Breast Cancer
1Department of Oncology, Kahramanmaraş Necip Fazıl City Hospital, Kahramanmaraş-Turkey2Department of Internal Diseases, Tarsus Medical Park Hospital, Mersin-Turkey
3Department of Oncology, Tarsus Medical Park Hospital, Mersin-Turkey
4Department of Oncology, Mersin University Faculty of Medicine, Mersin-Turkey OBJECTIVE
Breast cancer is a metastatic disease that frequently (in approximately 70% of cases) affects the skeletal system. The aim of the present study was to compare serum IL-18 levels in breast cancer patients with and without bone metastases with healthy controls.
METHODS
Included were a total of 154 female breast cancer patients with bone metastases (n=53; Group 2) and without
bone metastases (n=51; Group 1), as well as 50 healthy control subjects (Group 3). Serum IL-18 levels were
compared among the groups.
RESULTS
Mean serum IL-18 levels were significantly different between Groups 1 and 3 (p<0.001), Groups 2 and
3 (p<0.001), and Groups 2 and 1 (p=0.020). In receiver operating characteristic (ROC) curve analysis
performed between Groups 1 and 2, sensitivity of serum IL-18 levels in patients with bone metastases
was nearly 26 percent.
CONCLUSION
Lower rates of IL-18 sensitivity were detected in breast cancer patients with bone metastasis.