TURKISH JOURNAL OF ONCOLOGY 2026 , Vol 41 , Num 1
Independent Six-degree-of-freedom Accuracy Evaluation of BrainLab ExacTrac Dynamic and Varian CBCT Systems in Stereotactic Radiotherapy Using a Couch-based Reference
Deniz YALMAN1,Emin TAVLAYAN1,Yusuf Ziya HAZERAL1,Nezahat OLACAK1,Serra KAMER1
1Department of Radiation Oncology, Ege University Faculty of Medicine, İzmir-Türkiye DOI : 10.5505/tjo.2025.4737 OBJECTIVE
The study aims to evaluate the imaging and positioning accuracy of the BrainLab ExacTrac Dynamic System integrated with the Varian TrueBeam Linear Accelerator for stereotactic radiotherapy.

METHODS
BrainLab ExacTrac Dynamic System, BrainLab Phantom Pointer, and BrainLab Head Phantom were utilized. Imaging and positioning accuracy were assessed through manual and couch-induced displacement tests. This article does not contain any studies with human participants or animals performed by any of the authors. Ethical approval was not required for this study as it was conducted using phantoms only.

RESULTS
The study evaluated the accuracy of BrainLab ETD and Varian cone-beam computed tomography (CBCT) systems using a shared reference. Both systems demonstrated sub-millimeter precision, with translational errors ranging between 0.06 mm (ETD Z-axis) and 0.04 mm (ETD X-axis), and rotational errors below 0.12°. Maximum observed errors did not exceed 0.3 mm for translational or 0.2° for rotational movements. For combined errors 3D translational accuracy showed no significant difference p=0.482) between ETD (0.11 mm) and CBCT (0.09 mm). The 6D error magnitude was slightly lower for ETD (0.14 mm vs. 0.20 mm, p<0.001). Correlation analysis revealed that single-axis correlations between ETD and CBCT were not significant (p>0.05) except for pitch errors (p=0.023), which showed moderate correlation. The mean DIFF 6D vector (0.23 mm), representing the positional offset between ETD and CBCT detections, was significantly larger than both ETD 6D and CBCT 6D errors (p<0.001 and p=0.002, respectively).

CONCLUSION
Both systems offer high precision in detecting positional shifts. The ETD System"s ability to provide continuous, real-time monitoring enhances patient safety by allowing real-time correction of positioning errors, making it a valuable tool for stereotactic radiotherapy applications. Further studies with patient data are needed to validate the clinical application of these findings. Keywords : Cone-beam computed tomography; ExacTrac dynamic; stereotactic radiation therapy