1Trakya Üniversitesi Tıp Fakültesi, Medikal Onkoloji BD, Edirne PURPOSE
To review the Department of Radiation Oncology of Trakya University Medical School experience in the treatment of laryngeal carcinoma and to evaluate the different factors affecting locoregional control.
METHODS AND MATERIAL
We reviewed the records of 78 consecutive patients were treated for laryngeal carcinoma between July 1999 and November 2004. There were 74 men and 4 women, with a median age of 58 years (range, 34-80 years). Forty-two patients had T4 lesions, and 20 had T3 lesions; 32 had N0, 15 had N1, 27 had N2, and 2 had Nx disease. Surgery was the primary treatment modality in 34 patients. Twenty-six patients had RT alone, or chemotherapy combined with RT. Eighteen patients applied with locoregional or distant recurrent disease and they were given salvage or palliative treatment. x2 statistics were employed to identify significant factors for LRC.
RESULTS
The median follow-up was 18 months (range, 4-54 months). Twelve patients relapsed, of which 9 (26.5 %) locoregional failures among 34 patients of postoperative radiotherapy group. Significant prognostic factors for locoregional recurrence on univariate analysis were performance status, and surgical margin. Nine of 26 (34.6 %) patients relapsed and all of them had locoregional failures in primary radiotherapy group. Significant prognostic factors for these patients were primary tumor site, overall stage, T stage, and N stage.
CONCLUSION
Radiotherapy is effective in the treatment of laryngeal carcinoma. The identification of prognostic factors for locoregional recurrence could help to determine more effective treatment strategies.