TURKISH JOURNAL OF ONCOLOGY 2005 , Vol 20 , Num 2
CHEMOTHERAPY ASSOCIATED ANEMIA IN PATIENTS WITH SOLID TUMOR
1Dr. Hasan Şenol COŞKUN, 2Dr. Ozan YILMAZ, 2Dr. Osman AYDIN, 3Dr. Güçhan ALANOĞLU, 2Dr. Mehmet ŞAHİN, 4Dr. Özlem ER, 5Dr. İnci Ergürhan İLHAN
1Süleyman Demirel Üniversitesi Tıp Fakültesi Medikal Onkoloji Bilim Dalı, Isparta
2Süleyman Demirel Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Isparta
3Süleyman Demirel Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı, Isparta
4Erciyes Üniversitesi Tıp Fakültesi Medikal Onkoloji Bilim Dalı, Kayseri
5Süleyman Demirel Üniversitesi Zehra Ulusoy Onkoloji Merkezi, Isparta
Chemotherapy induced anemia is delayed toxicities of chemotherapy. Chemotherapy associated anemia was studied in eighty two patients. Patients divided 4 groups according to dominate chemotherapy drugs as follows fluorouracil (FU) 29 patients (35.4%), anthracycline 28 (34.1%), cisplatin 17 (20.7%), and taxane (9.8%). Median age was 59 years (range 35-80). Forty patients (48.8%) were female, 42 (51.2%) male. Patient's characteristcs were similar between groups. The median hemoglobin (Hb) level before chemotherapy was 12.3g/dl (8.8-16.7) and the median haemotocrit level was %36.5 (%27.7-49.1). The median Hb levels, before chemotherapy, were similar between the four groups. Patients had median 11.5 g/dl Hb level after chemotherapy. The difference between the Hb levels before and after chemotherapy was statistically significant (p=0.001). The decrease in Hb levels was statistically significant in the cisplatin and anthracycline groups but it was not significant in the FU and taxane groups. Seventeen patients (20.7%) had Hb levels under the 11.0 gr/dl before chemotherapy and this proportion was increased to 31 patients (%37.8) after chemotherapy. Chemotherapy associated anemia is frequenty and especially accompanies the protocols including cisplatin. Keywords : Chemotherapy, anemia, cisplatin