TURKISH JOURNAL OF ONCOLOGY 2017 , Vol 1 , Num 3
Hypofractıonated Preoperatıve Chemoradiotherapy In Locally Advanced Rectal Cancer: Preliminary Results
Sedenay OSKEROĞLU KAPLAN1,Halil AKBÖRÜ2,Selvi DİNÇER TABAK2,Serap BAŞKAYA YÜCEL5,İbrahim MERAL3,Yunus SARALI3,Selma ŞENGİZ ERHAN4,Süleyman ALTIN2
1Department of Radiation Oncology, Mehmet Akif İnan Training and Research Hospital, Şanlıurfa-Turkey
2Department of Radiation Oncology, Okmeydanı Training and Research Hospital, İstanbul-Turkey
3Department of Medical Physics, Okmeydanı Training and Research Hospital, İstanbul-Turkey
4Department of Pathology, Okmeydanı Training and Research Hospital, İstanbul-Turkey
5Department of Radiation Oncology, Acıbadem Mehmet Ali Aydınlar University Atakent Hospital, İstanbul-Turkey
DOI : 10.5505/tjo.2018.1869 OBJECTIVE
The aim of the present study was to evaluate the efficacy and safety of preoperative hypofractionated chemoradiotherapy in patients with locally advanced rectum cancer, which was previously observed in the Far East (KROG 11-02).

METHODS
Twenty-seven patients with locally advanced rectal cancer (cT3?4N0?2M0) between November 2014 and August 2016 were included in the study. A 2-week schedule of hypofractionated radiotherapy, 33 Gy/10 fractions, with concurrent 1 cycle of oral capecitabine (1650 mg/m2/day) was applied. Patients were scheduled to undergo surgery 6?8 weeks after completion of chemoradiotherapy. End points were tumor responses and toxicity.

RESULTS
All patients underwent total mesorectal excision except only one patient, and statistical analysis was performed on 26 patients. Of the patients, 10 (38.4%) were downstaged, and 3 (11.5%) had a pathologically complete response. No grade 3?4 toxicity was observed in the patient group. Grade 1?2 hematologic toxicity developed in 2 (8%) patients, and no biochemical abnormality was observed. Gastrointestinal toxicity was observed in 17 (65%), genitourinary toxicity in 8 (30%), and radiodermatitis in 3 (11%) patients. One patient had permanent anastomosis and wound dehiscence, and one patient had presacral abscess. Enterocutaneous fistula developed in only one patient.

CONCLUSION
A 2-week schedule of radiotherapy with oral capecitabine in patients with locally advanced rectal cancer resulted in similar toxicity levels and tumor response rate in comparison with previous results. Keywords : Capecitabine; hypofractioned radiotherapy; preoperative chemoradiotherapy; rectal cancer