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¹Celal Bayar Üniversitesi Fen Edebiyat Fakültesi, Biyoloji Bölümü, Moleküler Biyoloji Anabilim Dalı, Manisa
²Celal Bayar Üniversitesi Fen Bilimleri Enstitüsü, Biyoloji Anabilim Dalı, Moleküler Biyoloji Programı, Manisa Hydroxytyrosol is a phenolic compound released from the hydrolysis of oleuropein and is present in olive oil, leaf and fruit. Recently, studies on hydroxytyrosol have revealed its strong antioxidant and antiinflamatory effects. In vitro studies conducted in various cancer cell lines and in vivo assays carried out on animals reported strong evidences for its antiinflamatory, antiproliferative and proapoptotic influences. In addition, in cancer it is believed to have inhibitory effects during angiogenesis. Its modulatory role on bone formation and prevention of bone loss has been the attraction of some studies. If the molecular mechanisms and cellular pathways of hydroxytyrosol are elucidated, it will be possible to plan new strategies targeting various disease involved with cancer, inflammatory and cardio-vascular pathologies. In this review, various in vitro and in vivo studies investigating the antioxidant, anticancer, antiinflamatory role of hydroxytyrosol and its inhibitory effects in osteoporosis are discussed. Keywords : Antiinflamatory; anticancer; antioxidant; antiproliferative; hydroxytyrosol; proapoptotic