TURKISH JOURNAL OF ONCOLOGY 2017 , Vol 1 , Num 3
Long Term Follow-Up of Male Breast Cancer Patients, Single Center Experience
Burcu ÇAKAR1,Fatma SERT2,Pınar GÜRSOY1,Barış EMEKDAŞ3,Zeynep ÖZSARAN2,Erhan GÖKMEN1,Ayfer HAYDAROĞLU2
11Department of Medical Oncology, Ege University Faculty of Medicine, Tulay Aktas Oncology Hospital, Bornova, İzmir-Turkey
22Department of Radiation Oncology, Ege University Faculty of Medicine, Bornova, İzmir-Turkey
33Department of Internal Medicine, Ege University Faculty of Medicine, Bornova, İzmir-Turkey
DOI : 10.5505/tjo.2019.1957

Summary

OBJECTIVE
Male breast cancer (BC) represents <1% of all breast cancer cases. Our study aimed to define immunohistochemistry (IHC) based surrogate subtype distribution of male breast cancers and to define the recurrence pattern and survival among subgroups.

METHODS
Medical records of male BC patients admitted to Ege University School of Medicine, Medical Oncology and Radiation Oncology Clinics between 1998 and 2017 were retrospectively reviewed. Patient demographics, pathological feature of the primary tumor, adjuvant treatment options and survival data were analysed. Intrinsic breast cancer subtypes were defined according to estrogen receptor (ER), progesteron receptor(PR), HER-2 and ki-67 status.

RESULTS
We identified 58 male breast cancer patients. The median age at diagnosis was 59 years (IQR:30-78) and median follow-up was 83.7 months. Invasive ductal carcinoma was the most common histology (79.3%). 8.6% of the patients presented with stage 4 disease. 24 patients had (41.4%) luminal A-like, 28 (48.3%) had luminal B-like, 2(3.4%) had HER-2 positive, and 4 (6.9%) had triple negative (TNBC) breast cancer. 18 deaths were observed during follow-up. The overall survival (OS) and disease free survival( DFS) rates among breast cancer subgroups were not statistically significant. Median OS was 161 months (95% CI 94.7-228.4) in whole patient group. DFS was statistically related to initial tumor stage.

CONCLUSION
The disease onset was found at younger age with more locally advanced setting compared to literature. Luminal predominance was demonstrated. Initial stage but not breast cancer subtypes predict the risk of relapse in male breast cancer patients.