TURKISH JOURNAL OF ONCOLOGY 2017 , Vol 1 , Num 3
The Estimation of Thyroid Cancer Risk based on Type 2 Diabetes Mellitus and ABO Blood Group
Shahrokh KHOSHSIRAT1,Ali Asghar PEYVANDI1,Mahbobeh OROEI2,Hassan PEYVANDI3,Ali REZAEIFARD4
1Department of Otorhinolaryngology, Hearing Disorders Research Center, ShahidBeheshti University of Medical Sciences/Loghman Hakim Hospital, Tehran-Iran
2Hearing Disorders Research Center, ShahidBeheshti University of Medical Sciences/Loghman Hakim Hospital, Tehran-Iran
3Department of Surgery, ShahidBeheshti University of Medical Sciences/Loghman Hakim Hospital, Tehran-Iran
4Department of Health and Rehabilitation of Iranian Red Crescent Society, Tehran-Iran
DOI : 10.5505/tjo.2020.2066

Summary

OBJECTIVE
Multiple potential risk factors have been proposed for the development of thyroid cancer. Type 2 diabetes and ABO blood group had a significant relationship with some cancers. These agents may be related to thyroid cancer. This study investigates the association between thyroid cancer and diabetes and the ABO blood group.

METHODS
This analytic study was conducted in patients with thyroid cancer (n=87) and the individuals cancerfree (n=929). The odds ratio of thyroid cancer was estimated in diabetic patients after adjusting age and sex. The distribution of the blood groups in both groups was determined and compared with considering confidence interval 95%.

RESULTS
We observed a significant association between thyroid cancer and type 2 diabetes (odds ratio (OR): 4.42, 95% confidence interval (CI): 2.04-9.57, p<0.001). There was a significantly lower frequency of blood type A in patients with thyroid cancer (25.3%) compared to the control group (34.4%) with a reduced risk of 43% (OR: 0.57; 95% CI: 0.33?0.97, p=0.04 ). The patients with blood type B had a borderline risk of thyroid cancer (OR: 1.60, 95% CI: 0.96?2.70, p=0.07).

CONCLUSION
Our findings show the relationship between type 2 diabetes and thyroid cancer. The blood type A can significantly decrease the risk of thyroid cancer, and the blood type B may increase. To confirm these results, further studies should be conducted.