TURKISH JOURNAL OF ONCOLOGY 2017 , Vol 1 , Num 3
Survival and Treatment Outcomes in Patients with Extracranial Oligometastatic Breast Cancer: Single-Center Experience
Özlem MERMUT1,Didem Can TRABULUS2,Esra ARSLAN3,Mehmet Ali NAZLI4
1Department of Radiation Oncology, Health Sciences University, İstanbul Education and Research Hospital, İstanbul-Turkey
2Department of General Surgery, University of Health Sciences, İstanbul Education and Research Hospital, İstanbul-Turkey
3Department of Nuclear Medicine, University of Health Sciences, İstanbul Education and Research Hospital, İstanbul-Turkey
4Department of Radiology, Health Sciences University, İstanbul Education and Research Hospital, İstanbul-Turkey
DOI : 10.5505/tjo.2020.2278

Summary

OBJECTIVE
Oligometastatic tumors are usually characterized by a solitary or small number of metastatic lesions confined to a single organ. This study aims to investigate the prognostic factors for overall survival in patients with extracranial oligometastatic breast cancer and share our own experiences.

METHODS
We evaluated 130 patients who were admitted for the diagnosis of extracranial oligometastatic breast cancer at the University of Health Sciences Istanbul Training and Research Hospital Department of Radiation Oncology between 2013 and 2017.

RESULTS
Age (p=0.003), type of surgery (p<0.001), estrogen receptor status positivity (p=0.011), location of metastasis (p<0.001), premenopausal status (p=0.001), number of metastases (p=0.029), administration of chemotherapy (p<0.001) and application of curative radiotherapy (p<0.001) were the prognostic factors affecting overall survival in univariate analysis. Age<50 (HR: 5.434; 95% CI: 1.025-28.80; p=0.047), only bone metastasis (HR: 0.165; 95% CI: 0.073?0.370; p<0.001), premenopausal status (HR: 0.125; 95% CI: 0.022?0.723; p=0.020) and chemotherapy administration (HR: 4.342; 95% CI: 1.792?10.52; p=0.001) were independent prognostic factors that positively affected overall survival in multivariate analysis.

CONCLUSION
Oligometastatic breast cancer is a separate subgroup with long-term prognosis for patients with metastatic breast cancer. In patients with extracranial oligometastatic breast cancer, long-term disease control may be possible using more aggressive multidisciplinary treatments, particularly in patients with bone-only metastases.